Dr. Angela Laird

Angela R. Laird, Ph.D.
Associate Professor, Radiology

lairda@uthscsa.edu
(210) 567-8136 (Phone)
(210) 567-8152 (Fax)

Laird Lab Website
CogPO: An Ontology of Cognitive Paradigms


Education

2003
Research Imaging Institute, UTHSCSA
Post-Doc (Neuroinformatics)
2002
University of Wisconsin, Madison, WI
Ph.D. (Physics)
2001
University of Wisconsin, Madison, WI
M.S. (Physics)
1998
Florida State University, Tallahassee, FL
B.S. (Physics)


Research Interests

Dr. Laird’s research deals with integrating neuroinformatics tools and network analysis methods, such as structural equation modeling (SEM), activation likelihood estimation (ALE), and replicator dynamics network analysis (RDNA), in the field of human functional brain mapping.  Her expertise lies in meta-analysis of PET and fMRI data, which searches for regions of concordance across multiple studies.  In addition to her research and teaching duties, Dr. Laird is responsible for the administration and development of BrainMap, an online community database of functional neuroimaging data.

Recent Publications

  1. Glahn DC, Laird AR, Ellison-Wright I, Thelen SM, Robinson JL, Lancaster JL, Bullmore E, Fox PT. Meta-analysis of gray matter anomalies in schizophrenia: Application of anatomic likelihood estimation and network analysis. Biol Psychiatry, In Press.
  2. Price LR, Laird AR, Fox PT. Modeling dynamic functional neuroimaging data using structural equation modeling. Structural Equation Modeling, In Press.
  3. Witt ST, Laird AR, Meyerand ME. Functional neuroimaging correlates of finger tapping task variations: An ALE meta-analysis. Neuroimage 42, 343-356, 2008.
  4. Laird AR, Robbins JM, Li K, Price LR, Cykowski MD, Narayana S, Laird RW, Franklin C, Fox PT. Modeling motor connectivity using TMS/PET and structural equation modeling. Neuroimage 41, 424-436, 2008.
  5. Ellison-Wright I, Glahn DC, Laird AR, Thelen SM, Bullmore ET. The anatomy of first-episode and chronic schizophrenia: An anatomical likelihood estimation meta-analysis. Am J Psych 165, 1015-1023, 2008.
  6. Cykowski M, Coulon O, Kochunov PV, Amunts K, Lancaster JL, Laird AR, Glahn DC, Fox PT. The central sulcus: An observer-independent characterization of sulcal landmarks and depth asymmetry. Cerebral Cortex 18, 1999-2009, 2008.
  7. Laird AR, Lancaster JL, Fox PT. Functional brain mapping and activation likelihood estimation meta-analysis. In: Dhawan AP, Huang HK, Kim DS, editors. Principles and Recent Advances in Medical Imaging and Image Analysis. Hackensack, New Jersey: World Scientific, May 2008.
  8. Fitzgerald PB, Laird AR, Maller J, Daskalakis ZJ. A meta-analytic study of changes in brain activation in depression. Hum Brain Mapp 29, 683-695, 2008.
  9. Menzies LAC, Chamberlain SR, Laird AR, Thelen SM, Sahakian BJ, Bullmore ET. Integrating evidence from neuroimaging and neuropsychological studies of obsessive compulsive disorder: The orbitofronto-striatal model revisited. Neurosci Biobehav Rev 32, 525-549, 2008.
  10. Kochunov P, Thompson PM, Lancaster JL, Bartzokis G, Smith S, Coyle T, Royall DR, Laird A, Fox PT. Relationship between white matter fractional anisotropy and other indices of cerebral health in normal aging: Tract-based spatial statistics study of aging. Neuroimage 35, 478-87, 2007.
  11. McMillan KM, Rogers BP, Koay CG, Laird AR, Price RR, Meyerand ME. An objective method for combining multi-parametric MRI datasets to characterize malignant tumors. Med Phys 34, 1053-1061, 2007.
  12. McMillan KM, Laird AR, Witt ST, Meyerand ME. Self-paced working memory: Validation of verbal variations of the n-back paradigm. Brain Research 1139, 133-142, 2007.
  13. McMillan KM, Rogers BP, Field AS, Laird AR, Fine JP, Meyerand ME. Physiologic characterisation of glioblastoma multiforme using MRI-based hypoxia mapping, chemical shift imaging, perfusion, and diffusion maps. J Clin Neurosci 13, 811-817, 2006.
  14. Fitzgerald PB, Oxley TJ, Laird AR, Kulkarni J, Egan GF, Daskalakis ZJ. An analysis of functional neuroimaging studies of dorsolateral prefrontal cortical activity in depression. Psychiatry Res 148, 33-45, 2006.
  15. Kochunov P, Lancaster JL, Glahn DC, Purdy D, Laird AR, Gao F, Fox P. Retrospective motion correction protocol for high-resolution anatomical MRI. Hum Brain Mapp, 27, 957-962, 2006.
  16. Fox PT, Laird AR, Lancaster JL.  Coordinate-based voxel-wise meta-analysis:  Dividends of spatial normalization.  A report of a virtual workshop.  Hum Brain Mapp 25, 1-5, 2005.
  17. Laird AR, McMillan KM, Lancaster JL, Kochunov P, Turkeltaub PE, Pardo JV, Fox PT. A comparison of label-based review and activation likelihood estimation in the Stroop task.  Hum Brain Mapp 25, 6-21, 2005.
  18. Owen AM, McMillan KM, Laird AR, Bullmore E.  N-back working memory paradigm: A meta-analysis of normative functional neuroimaging studies. Hum Brain Mapp 25, 46-59, 2005.
  19. Glahn DC, Ragland JD, Abramoff A, Barrett J, Laird AR, Bearden CE, Velligan DI.  Beyond hypofrontality: A quantitative meta-analysis of functional neuroimaging studies of working memory in schizophrenia.  Hum Brain Mapp 25, 60-69, 2005.
  20. Price CJ, Devlin JT, Moore CJ, Morton C, Laird AR.  Meta-analyses of object naming: Effect of baseline.  Hum Brain Mapp 25, 70-82, 2005.
  21. Tan L-H, Laird AR, Li K, Fox PT.  Neuroanatomical correlates of phonological processing of Chinese characters and alphabetic words: A meta-analysis.  Hum Brain Mapp 25, 83-91, 2005.
  22. Brown S, Laird AR, Ingham RJ, Ingham JC, Fox PT.  Stuttered and fluent speech production:  An ALE meta-analysis of functional neuroimaging studies.  Hum Brain Mapp 25, 105-117, 2005.
  23. Petacchi A, Laird AR, Fox PT, Bower JM.  Cerebellum and auditory function: An ALE meta-analysis of functional neuroimaging studies.  Hum Brain Mapp 25, 118-128, 2005.
  24. Farrell MJ, Laird AR, Egan GF.  Brain activity associated with painfully hot stimuli applied to the upper limb: A meta-analysis.  Hum Brain Mapp  25, 129-139, 2005.
  25. Grosbras M-H, Laird AR, Paus T.  Cortical regions involved in eye movements, shifts of attention, and gaze perception.  Hum Brain Mapp 25, 140-154, 2005.
  26. Laird AR, Fox M, Price CJ, Glahn DC, Uecker AM, Lancaster JL, Turkeltaub PE, Kochunov P, Fox PT. ALE meta-analysis: Controlling the false discovery rate and performing statistical contrasts.   Hum Brain Mapp 25, 155-164, 2005.
  27. Lancaster JL, Laird AR, Fox M, Glahn DE, Fox PT.  Automated analysis of meta-analysis networks.  Hum Brain Mapp 25, 174-184, 2005.
  28. Fox PT, Laird AR, Fox SP, Fox M, Uecker AM, Crank M, Koenig SF, Lancaster JL.  BrainMap taxonomy of experimental design: Description and evaluation.  Hum Brain Mapp 25, 185-198, 2005.
  29. Laird AR, Lancaster JL, Fox PT.  BrainMap:  The social evolution of a functional neuroimaging database.  Neuroinformatics 3, 65-78, 2005.
  30. Kochunov P, Lancaster JL, Hardies J, Thompson P, Woods R, Cody J, Hale D, Laird AR, Fox PT.  Mapping structural differences of the corpus callosum in individuals with 18q deletions using targetless regional spatial normalization.  Hum Brain Mapp 24, 325-331, 2005.
  31. Laird AR, Rogers BP, Meyerand ME.  Comparison of Fourier and wavelet resampling methods.  Magn Reson Med 51: 418-422, 2004.
  32. Laird AR, Rogers BP, Carew JD, Arfanakis K, Moritz CM, Meyerand ME.  Characterizing instantaneous phase relationships in whole-brain fMRI activation data, Hum Brain Mapp 16:71-80, 2002.

Teaching

Dr. Laird serves as instructor for the graduate course entitled “Meta-Analysis in Cognitive Neuroimaging” that is cross-listed as an interdisciplinary course at UTHSCSA (INTD 5046) and in the biology and psychology departments at UTSA (BIO 6973 and PSY 6973).  In this course, students are guided in choosing a meta-analysis topic, searching Medline to find the relevant literature, coding the papers into BrainMap, and performing an ALE meta-analysis.  At the end of the semester, students give an oral presentation of their results and write a term paper written in traditional scientific format.

Honors and Awards

2005
Special Guest Editor for Human Brain Mapping Special Issue on Meta-Analysis in Functional Neuroimaging
2002
Hirschfelder Award, University of Wisconsin, Madison, WI
2002
IEEE EMBS-BMES Special Travel Award for Presenting Authors
2001
UW-Madison Graduate Student Council Vilas Travel Award
2000
Committee on Institutional Cooperation (CIC) Women in Science and Engineering (WISE) Travel Grant
1998
Chen Distinguished Graduate Fellowship
1998
Van Vleck Fellowship for Graduate Students in Physics


Funding

1. NIH / 1 R01 MH074457-01 Fox (PI) / Role: Co-Investigator
9/15/06 – 8/31/10
“Meta-analysis in Human Brain Mapping.”
The overall goal of this project is to develop, evaluate, distribute, and apply tools for quantitative meta-analysis of the human functional brain mapping (HFBM) literature.

2. NIH / 5 R01 DC001150-16A1 Ramig (PI) / Role: Co-Investigator
9/20/2007 – 8/31/2012
“Efficacy of Voice Treatment for Parkinson‘s Disease.”
Parkinson's Disease (PD) hypophonia and dysprosodia improve with LSVT. The central mechanisms involved in such treatment effects are unknown. In the present project, these mechanisms will be investigated in 10 PD patients pre- and post-LSVT and 10 matched controls with behavior and functional neuroimaging (Positron Emission Tomography or PET).

3. NIH / 1 R01 MH080912-01 Glahn (PI) / Role: Co-Investigator
5/01/08 – 1/31/13
“Influence of Psychosis on Brain-Behavior Endophenotypes for Bipolar Disorder.”
The ultimate promise of this research is to develop markers that will facilitate the discovery of genes that predispose to BPI and/or psychosis and will help characterize the brain-behavior impact of genes putatively associated with these illnesses.